Thanos is MCU's biggest villian who came in his full glory in Infinity War and Endgame. With infinity gauntlet he was impossible to be defeated and thus he created the blip but have you ever imagine who are some MCU beings who can defeat him without infinity gauntlet. 

This is Thanos (without the Infinity Gauntlet) :

Let's see

10 Characters Who Could Defeat Thanos (without the Infinity Gauntlet) :

1. Thor (Infinity War)

He almost defeated Thanos with all the infinity stones. He is the God of Thunder and got even powerful when he awakened his abilities. He would be able to defeat Thanos easily.

2. Doctor Strange

Doctor Strange is the Sorcerer Supreme. He is also the Master of the Mystic Arts. He stood his ground against Thanos when he held four infinity stones. He would easily defeat Thanos with the infinity stones.

3. Scarlett Witch ( Endgame) 

She was full of rage in Avengers:Endgame. She is wanted to take revenge from Thanos for killing Vision. She was going to defeat Thanos but he rained fire. In this case, he doesn't have his army, so Scarlet Witch would tear him apart.

4. Binary Captain Marvel

Binary Captain Marvel has a lot of advantages against Thanos. She has a flying advantage as well immense physical strength and incredible speed. She would be able to defeat Thanos.

5. Prime Hela

Hela is the Goddess of Death. She is stronger than awakened Thor. She killed a whole army of Valkyrie single-handedly. She is only a little less powerful than Odin so she would easily defeat Thanos.

6. Ego

Ego is a living planet as well as a celestial. He has experience of millions of years and has full control of his powers. Thanos wouldn't stand a chance against him.

7. Dormammu

Dormammu is the Lord of the Dark Dimension. Thanos is nothing compared to him. He can absolutely smash and destroy Thanos in seconds.

8. Surtur

This Surtur has Odin’s curse. He threw the Hulk without any effort and killed Hela in a hit. He destroyed a whole planet in a few minutes. Thanos can't do anything against him.

9. Prime Odin

Odin is the Allfather. He is the father of Thor, Loki and Hela who themselves are extremely powerful. He took away the powers of Thor and imprisoned Hela in Hel. There is no way Thanos would defeat Prime Odin.

10. Ancient One

The Ancient One was the Sorceress Supreme before Doctor Strange. She is the teacher of Doctor Strange. She has an experience of many centuries and is very powerful. Drawing power from the Dark Dimension made her so much powerful. She would absolutely destroy Thanos.